iroa workflow Search Results


iroa workflow  (IROA Technologies LLC)
94
IROA Technologies LLC iroa workflow
a <t>The</t> <t>IROA</t> ion suppression correction <t>workflow.</t> b Number of MSTUS peaks detected across analytical conditions. c–k Raw MSTUS-12C (blue lines) and suppression-corrected MSTUS-12C (red lines) values are shown for: c HILIC positive mode, uncleaned source; d HILIC positive mode, clean source; e HILIC negative mode, uncleaned source; f HILIC negative mode, clean source; g RPLC positive mode, uncleaned source; h RPLC positive mode, clean source; ( i ) RPLC negative mode, uncleaned source; j RPLC negative mode, clean source; and k IC negative mode, cleaned source. l Ratio of raw MSTUS-12C to suppression-corrected MSTUS-12C peak intensity across chromatographic methods and experimental conditions. m Raw and suppression-corrected phenylalanine values in RPLC positive ionization mode with cleaned source. n Raw and suppression-corrected pyroglutamylglycine values in IC negative ionization mode. o Identified chemical composition in entire RPLC clean dataset, as an example. p Kohonen Self Organizing Maps (SOM) show suppression patterns in the RPLC Clean raw dataset for all 539 compounds. q Density map shows compounds associated with each of the patterns discovered in ( o ). r Raw MSTUS-12C (blue lines) and suppression-corrected MSTUS-12C (red lines) values are shown for RPLC positive mode and RPLC negative mode ( s ) for urine. t Ratio of raw MSTUS-12C to suppression-corrected 12 C peak intensity for urine matrix in positive and negative ion modes. u Plasma and urine MSTUS-12C signals for 4 common metabolites before and after suppression correction. 12C SC = 12C suppression corrected MSTUS; 13C raw = 13C raw MSTUS. Colors represent percent peak intensity as indicated by the color bar. Source data are provided as a Source Data file. Data are shown as mean ± s.d. ( c – n , r , s ).
Iroa Workflow, supplied by IROA Technologies LLC, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/iroa workflow/product/IROA Technologies LLC
Average 94 stars, based on 1 article reviews
iroa workflow - by Bioz Stars, 2026-02
94/100 stars
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iroa workflow  (Genedata Inc)
90
Genedata Inc iroa workflow
a <t>The</t> <t>IROA</t> ion suppression correction <t>workflow.</t> b Number of MSTUS peaks detected across analytical conditions. c–k Raw MSTUS-12C (blue lines) and suppression-corrected MSTUS-12C (red lines) values are shown for: c HILIC positive mode, uncleaned source; d HILIC positive mode, clean source; e HILIC negative mode, uncleaned source; f HILIC negative mode, clean source; g RPLC positive mode, uncleaned source; h RPLC positive mode, clean source; ( i ) RPLC negative mode, uncleaned source; j RPLC negative mode, clean source; and k IC negative mode, cleaned source. l Ratio of raw MSTUS-12C to suppression-corrected MSTUS-12C peak intensity across chromatographic methods and experimental conditions. m Raw and suppression-corrected phenylalanine values in RPLC positive ionization mode with cleaned source. n Raw and suppression-corrected pyroglutamylglycine values in IC negative ionization mode. o Identified chemical composition in entire RPLC clean dataset, as an example. p Kohonen Self Organizing Maps (SOM) show suppression patterns in the RPLC Clean raw dataset for all 539 compounds. q Density map shows compounds associated with each of the patterns discovered in ( o ). r Raw MSTUS-12C (blue lines) and suppression-corrected MSTUS-12C (red lines) values are shown for RPLC positive mode and RPLC negative mode ( s ) for urine. t Ratio of raw MSTUS-12C to suppression-corrected 12 C peak intensity for urine matrix in positive and negative ion modes. u Plasma and urine MSTUS-12C signals for 4 common metabolites before and after suppression correction. 12C SC = 12C suppression corrected MSTUS; 13C raw = 13C raw MSTUS. Colors represent percent peak intensity as indicated by the color bar. Source data are provided as a Source Data file. Data are shown as mean ± s.d. ( c – n , r , s ).
Iroa Workflow, supplied by Genedata Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/iroa workflow/product/Genedata Inc
Average 90 stars, based on 1 article reviews
iroa workflow - by Bioz Stars, 2026-02
90/100 stars
  Buy from Supplier

Image Search Results


a The IROA ion suppression correction workflow. b Number of MSTUS peaks detected across analytical conditions. c–k Raw MSTUS-12C (blue lines) and suppression-corrected MSTUS-12C (red lines) values are shown for: c HILIC positive mode, uncleaned source; d HILIC positive mode, clean source; e HILIC negative mode, uncleaned source; f HILIC negative mode, clean source; g RPLC positive mode, uncleaned source; h RPLC positive mode, clean source; ( i ) RPLC negative mode, uncleaned source; j RPLC negative mode, clean source; and k IC negative mode, cleaned source. l Ratio of raw MSTUS-12C to suppression-corrected MSTUS-12C peak intensity across chromatographic methods and experimental conditions. m Raw and suppression-corrected phenylalanine values in RPLC positive ionization mode with cleaned source. n Raw and suppression-corrected pyroglutamylglycine values in IC negative ionization mode. o Identified chemical composition in entire RPLC clean dataset, as an example. p Kohonen Self Organizing Maps (SOM) show suppression patterns in the RPLC Clean raw dataset for all 539 compounds. q Density map shows compounds associated with each of the patterns discovered in ( o ). r Raw MSTUS-12C (blue lines) and suppression-corrected MSTUS-12C (red lines) values are shown for RPLC positive mode and RPLC negative mode ( s ) for urine. t Ratio of raw MSTUS-12C to suppression-corrected 12 C peak intensity for urine matrix in positive and negative ion modes. u Plasma and urine MSTUS-12C signals for 4 common metabolites before and after suppression correction. 12C SC = 12C suppression corrected MSTUS; 13C raw = 13C raw MSTUS. Colors represent percent peak intensity as indicated by the color bar. Source data are provided as a Source Data file. Data are shown as mean ± s.d. ( c – n , r , s ).

Journal: Nature Communications

Article Title: Ion suppression correction and normalization for non-targeted metabolomics

doi: 10.1038/s41467-025-56646-8

Figure Lengend Snippet: a The IROA ion suppression correction workflow. b Number of MSTUS peaks detected across analytical conditions. c–k Raw MSTUS-12C (blue lines) and suppression-corrected MSTUS-12C (red lines) values are shown for: c HILIC positive mode, uncleaned source; d HILIC positive mode, clean source; e HILIC negative mode, uncleaned source; f HILIC negative mode, clean source; g RPLC positive mode, uncleaned source; h RPLC positive mode, clean source; ( i ) RPLC negative mode, uncleaned source; j RPLC negative mode, clean source; and k IC negative mode, cleaned source. l Ratio of raw MSTUS-12C to suppression-corrected MSTUS-12C peak intensity across chromatographic methods and experimental conditions. m Raw and suppression-corrected phenylalanine values in RPLC positive ionization mode with cleaned source. n Raw and suppression-corrected pyroglutamylglycine values in IC negative ionization mode. o Identified chemical composition in entire RPLC clean dataset, as an example. p Kohonen Self Organizing Maps (SOM) show suppression patterns in the RPLC Clean raw dataset for all 539 compounds. q Density map shows compounds associated with each of the patterns discovered in ( o ). r Raw MSTUS-12C (blue lines) and suppression-corrected MSTUS-12C (red lines) values are shown for RPLC positive mode and RPLC negative mode ( s ) for urine. t Ratio of raw MSTUS-12C to suppression-corrected 12 C peak intensity for urine matrix in positive and negative ion modes. u Plasma and urine MSTUS-12C signals for 4 common metabolites before and after suppression correction. 12C SC = 12C suppression corrected MSTUS; 13C raw = 13C raw MSTUS. Colors represent percent peak intensity as indicated by the color bar. Source data are provided as a Source Data file. Data are shown as mean ± s.d. ( c – n , r , s ).

Article Snippet: Using the IROA Workflow, analysts can err on the side of injecting larger sample volumes to ensure robust measurement of low-abundance analytes while simultaneously performing ion suppression correction to achieve more accurate results.

Techniques: Hydrophilic Interaction Liquid Chromatography

a Optimization of cancer cell count for the IROA-IS ion suppression correction workflow. Raw MSTUS-12C (blue lines), suppression-corrected MSTUS-12C (red lines), and DUAL-MSTUS normalized (green lines) values are shown for: b RPLC positive mode, cleaned source; and c RPLC negative mode, clean source. d Optimization of IROA-IS during extraction and during reconstitution for ion suppression correction workflow. e Identified chemical composition in OVCAR-8 cell using IROA-IS in extraction solvent for entire RPLC clean dataset by both positive and negative mode. f Identified chemical composition in OVCAR-8 cell using IROA-IS as reconstitute solvent for entire RPLC clean dataset by both positive and negative mode. g Identified chemical composition in OVCAR-4 cell using IROA-IS in extraction solvent for entire RPLC clean dataset by both positive and negative mode. h Identified chemical composition in OVCAR-4 cell using IROA-IS as reconstitute solvent for entire RPLC clean dataset by both positive and negative mode. i Percent coefficient of variation (%CV) for raw, suppression-corrected, and normalized data from OVCAR-8 cell using IROA-IS in extraction solvent for entire RPLC clean dataset by both positive and negative mode. j Percent coefficient of variation (%CV) for raw, suppression-corrected, and normalized data from OVCAR-8 cell using IROA-IS as reconstitute solvent for entire RPLC clean dataset by both positive and negative mode. k Percent coefficient of variation (%CV) for raw, suppression-corrected, and normalized data from OVCAR-4 cell using IROA-IS in extraction solvent for entire RPLC clean dataset by both positive and negative mode. l Percent coefficient of variation (%CV) for raw, suppression-corrected, and normalized data from OVCAR-4 cell using IROA-IS as reconstitute solvent for entire RPLC clean dataset by both positive and negative mode. Percent coefficient of variation (%CV) for non-IROA-driven raw, and IROA-driven raw, suppression-corrected, and normalized data from OVCAR-4 ( m ) and OVCAR-8 ( n ) cell lines, respectively, for entire RPLC clean dataset by both positive and negative mode. Colors represent percent peak intensity as indicated by the color bar. Source data are provided as a Source Data file. Data are shown as mean ± s.d. ( b , c ).

Journal: Nature Communications

Article Title: Ion suppression correction and normalization for non-targeted metabolomics

doi: 10.1038/s41467-025-56646-8

Figure Lengend Snippet: a Optimization of cancer cell count for the IROA-IS ion suppression correction workflow. Raw MSTUS-12C (blue lines), suppression-corrected MSTUS-12C (red lines), and DUAL-MSTUS normalized (green lines) values are shown for: b RPLC positive mode, cleaned source; and c RPLC negative mode, clean source. d Optimization of IROA-IS during extraction and during reconstitution for ion suppression correction workflow. e Identified chemical composition in OVCAR-8 cell using IROA-IS in extraction solvent for entire RPLC clean dataset by both positive and negative mode. f Identified chemical composition in OVCAR-8 cell using IROA-IS as reconstitute solvent for entire RPLC clean dataset by both positive and negative mode. g Identified chemical composition in OVCAR-4 cell using IROA-IS in extraction solvent for entire RPLC clean dataset by both positive and negative mode. h Identified chemical composition in OVCAR-4 cell using IROA-IS as reconstitute solvent for entire RPLC clean dataset by both positive and negative mode. i Percent coefficient of variation (%CV) for raw, suppression-corrected, and normalized data from OVCAR-8 cell using IROA-IS in extraction solvent for entire RPLC clean dataset by both positive and negative mode. j Percent coefficient of variation (%CV) for raw, suppression-corrected, and normalized data from OVCAR-8 cell using IROA-IS as reconstitute solvent for entire RPLC clean dataset by both positive and negative mode. k Percent coefficient of variation (%CV) for raw, suppression-corrected, and normalized data from OVCAR-4 cell using IROA-IS in extraction solvent for entire RPLC clean dataset by both positive and negative mode. l Percent coefficient of variation (%CV) for raw, suppression-corrected, and normalized data from OVCAR-4 cell using IROA-IS as reconstitute solvent for entire RPLC clean dataset by both positive and negative mode. Percent coefficient of variation (%CV) for non-IROA-driven raw, and IROA-driven raw, suppression-corrected, and normalized data from OVCAR-4 ( m ) and OVCAR-8 ( n ) cell lines, respectively, for entire RPLC clean dataset by both positive and negative mode. Colors represent percent peak intensity as indicated by the color bar. Source data are provided as a Source Data file. Data are shown as mean ± s.d. ( b , c ).

Article Snippet: Using the IROA Workflow, analysts can err on the side of injecting larger sample volumes to ensure robust measurement of low-abundance analytes while simultaneously performing ion suppression correction to achieve more accurate results.

Techniques: Cell Counting, Extraction, Solvent